Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity
Z. Jing, P. Galbo, L. Ovando, M. Demouth, S. Welte, R. Park, K. Chandran, Y. Wu, T. MacCarthy, D. Zheng, D. Fooksman
This study identifies unique features of long-lived plasma cells (LLPCs), including reduced motility, clustering, and specific surface markers, and shows that CXCR4 is critical for their survival and antibody production.
bioRxiv · Feb 15, 2023Immunology