T. MacCarthy

Evolvability of cancer-associated genes under APOBEC3A/B selection

The paper investigates how APOBEC3A/B activity influences the evolvability of cancer-associated genes compared to non-cancer genes across humans and bats, finding bimodal mutation patterns and increased cancer heterogeneity.

Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity

This study identifies unique features of long-lived plasma cells (LLPCs), including reduced motility, clustering, and specific surface markers, and shows that CXCR4 is critical for their survival and antibody production.

Beta human papillomavirus 8E6 promotes alternative end-joining

This study shows HPV8 E6 promotes alternative end-joining (Alt-EJ) by interacting with p300, leading to increased genomic instability and deletions with Alt-EJ signatures.

Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice

This study compares Exo1DA/DA mice with nuclease-dead EXO1 to Exo1-/- and Exo1+/+ mice to show EXO1 has both enzymatic and scaffolding roles in DNA repair, immune response, and tumor suppression.

Deep learning model of somatic hypermutation reveals importance of sequence context beyond targeting of AID and Polη hotspots

The paper develops a deep learning model to predict somatic hypermutation, showing that sequence context beyond AID and Polη hotspots significantly influences mutation patterns.