ImmunologybioRxiv
Memory CD8+ T cells mediate early pathogen-specific protection through localized delivery of chemokines and IFNγ to clusters of inflammatory monocytes
M. Boutet, Z. Benet, E. Guillen…·G. Lauvau
This study shows memory CD8+ T cells use cognate antigen to rapidly produce chemokines and IFNγ in splenic monocyte clusters, providing early pathogen protection before clonal expansion.
DOI 10.1126/sciadv.abf9975