P. Tian

Epigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity

This study identifies a noncanonical function of ZMYND11 as an arginine-methylated HNRNPA1 reader that suppresses stress granule formation and tumor progression.

Granzyme B-based CAR T cells block metastasis by eliminating circulating tumor cells

This study develops GrB-CAR T cells targeting mHSP70 to eliminate CTCs and inhibit metastasis in solid tumors.

RFX6 at locus 6q22 confers metastasis and drug resistance in prostate cancer

This study identifies RFX6 at locus 6q22 as a driver of prostate cancer metastasis and drug resistance through epigenetic and genetic mechanisms.

Kidney organoids: A system to study human basement membrane assembly in health and disease

This study uses kidney organoids to investigate basement membrane assembly dynamics, identifying conserved temporal patterns and pathogenic variant effects.

Exploring the Sequence Fitness Landscape of a Bridge Between Protein Folds

The paper develops a computational model to predict fold-switching sequences between GA and GB domains of protein G, identifying pathways and showing that low stability sequences are more likely to switch folds.

The ribosome modulates folding inside the ribosomal exit tunnel

The paper investigates how the ribosomal exit tunnel affects the folding of a small zinc-finger domain, finding that electrostatic interactions, not just confinement, contribute to folding acceleration and stabilization.

Cotranslational folding cooperativity of contiguous domains of α-spectrin

The paper investigates how adjacent domains of α-spectrin influence each other's cotranslational folding and estimates the mechanical force exerted during this process.

The Shape of the Ribosome Exit Tunnel Affects Cotranslational Protein Folding

The study shows that the geometry of the E. coli ribosome exit tunnel influences where proteins fold during translation, with larger domains folding deeper when tunnel space is available.

Monte Carlo Sampling of Protein Folding by Combining an All-Atom Physics-Based Model with a Native State Bias

The paper introduces a hybrid protein folding model, ProfasiGo, combining all-atom physics-based and structure-based potentials, and applies it to study folding free energy landscapes of four proteins.

The Folding Pathway of an Ig Domain is Conserved On and Off the Ribosome

The paper shows that the folding pathway of the titin I27 domain is conserved whether folding occurs on or off the ribosome.

A small single-domain protein folds through the same pathway on- and off- the ribosome

This study shows the src SH3 domain folds through the same pathway whether on or off the ribosome, suggesting the ribosome does not alter its folding mechanism.