Author

D. Gentien

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:dimensionality reduction· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Rapinat· 2 shared F. Reyal· 2 shared A. Brisson· 1 shared A. Eeckhoutte· 1 shared A. Nicolas· 1 shared A. Puisieux· 1 shared A. Vincent-Salomon· 1 shared A.-S. Hamy-Petit· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCancer Biology

A. Rapinat

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Plakins are involved in the maintenance of epithelial polarity

J. Geay, Y. Margaron, D. Gentien, F. Reyal, A. Puisieux, L. Blanchoin, L. Guyon, M. Thery

The paper identifies plakins as regulators of epithelial polarity by showing their downregulation in polarity loss and EMT progression, and demonstrates their causal role through experimental knockdown.

bioRxiv · Oct 16, 2023 · PreprintCell Biology

Optical Genome Mapping for detecting Homologous Recombination Deficiency (HRD) in human breast and ovarian cancers

S. Vanhuele, Y. Kirova, A.-S. Hamy-Petit, A. Rapinat, D. Gentien, C. Callens, M.-C. Villy, F. Reyal, A. Vincent-Salomon, A. Eeckhoutte, M. Rodrigues, M.-H. Stern, T. Popova

This study uses Optical Genome Mapping to detect HRD in breast and ovarian cancers by analyzing structural variants, finding isolated translocations as a reliable biomarker.

bioRxiv · Dec 23, 2022 · PreprintCancer Biology

Epigenomic mapping identifies a super-enhancer repertoire that regulates cell identity in bladder cancers through distinct transcription factor networks

H. Neyret-Kahn, J. Fontugne, X.-Y. Meng, C. S. Groeneveld, L. Cabel, T. Ye, E. Guyon, C. Krucker, F. Dufour, E. Chapeaublanc, A. Rapinat, D. C. B. Jeffery, Y. Neuzillet, T. Lebret, D. Gentien, , F. Radvanyi

The paper identifies super-enhancer networks regulating bladder cancer subtypes through transcription factors, showing their role in cell identity and inflammatory response suppression.

bioRxiv · Jan 11, 2022Cancer Biology

PRMT1 regulates EGFR and Wnt signaling pathways and is a promising target for combinatorial treatment of breast cancer

S. Suresh, S. Huard, A. Brisson, F. Nemati, C. Poulard, M. Ye, E. Martel, C. Reyes, D. C. Silvestre, D. Meseure, A. Nicolas, D. Gentien, M. Le Romancer, D. Decaudin, S. Roman-Roman, T. Dubois

This study identifies PRMT1 as a key regulator of EGFR and Wnt signaling in breast cancer and shows that targeting it with inhibitors can enhance chemotherapy and EGFR inhibitor efficacy in TNBC.

bioRxiv · Oct 22, 2021Cancer Biology