ImmunologybioRxivPreprint
Evolutionarily conserved effects of Notch signaling drive intestinal graft-versus-host disease in mice and non-human primates
V. Tkachev, A. Vanderbeck, E. Perkey…·I. Maillard
This study shows that Notch signaling, specifically through DLL4, promotes intestinal GVHD in mice and non-human primates by enhancing effector T-cell infiltration and reducing regulatory T-cell activity.
DOI 10.1101/2022.04.23.488844