Evolutionarily conserved effects of Notch signaling drive intestinal graft-versus-host disease in mice and non-human primates
V. Tkachev, A. Vanderbeck, E. Perkey, S. N. Furlan, C. McGuckin, D. Gomez Atria, U. Gerdemann, X. Rui, J. Lane, D. J. Hunt, H. Zheng, L. Colonna, M. Hoffman, A. Yu, S. Kelly, , I. Maillard
This study shows that Notch signaling, specifically through DLL4, promotes intestinal GVHD in mice and non-human primates by enhancing effector T-cell infiltration and reducing regulatory T-cell activity.
bioRxiv · Apr 23, 2022 · PreprintImmunology