Author

V. Tkachev

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Organism:non-human primate· 4 Assay:scRNA-seq· 4 Research Focus:differential expression· 3 Research Focus:cell signaling & trafficking· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

L. S. Kean· 5 shared C. McGuckin· 4 shared U. Gerdemann· 4 shared B. R. Blazar· 3 shared J. Kaminski· 3 shared S. N. Furlan· 3 shared X. Rui· 3 shared A. K. Shalek· 2 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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5 shared papersImmunology

L. S. Kean

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5 papers

Recent·Most cited

B cell directed CAR-T cell therapy results in activation of CD8+ cytotoxic CAR-negative bystander T cells in both non-human primates and patients

J. Kaminski, R. A. Fleming, F. Alvarez-Calderon, C. McGuckin, E. E. Ho, F. Eng, X. Rui, P. Keskula, L. Cagnin, J. Charles, J. Zavistaski, S. P. Margossian, M. A. Kapadia, J. B. Rottman, J. Lane, , U. Gerdemann

The paper identifies a novel mechanism where CAR-T cell therapy activates CD8+ cytotoxic bystander T cells in non-human primates and patients, showing they can kill leukemic cells independently of TCR.

bioRxiv · Sep 28, 2023 · PreprintImmunology

Evolutionarily conserved effects of Notch signaling drive intestinal graft-versus-host disease in mice and non-human primates

V. Tkachev, A. Vanderbeck, E. Perkey, S. N. Furlan, C. McGuckin, D. Gomez Atria, U. Gerdemann, X. Rui, J. Lane, D. J. Hunt, H. Zheng, L. Colonna, M. Hoffman, A. Yu, S. Kelly, , I. Maillard

This study shows that Notch signaling, specifically through DLL4, promotes intestinal GVHD in mice and non-human primates by enhancing effector T-cell infiltration and reducing regulatory T-cell activity.

bioRxiv · Apr 23, 2022 · PreprintImmunology

Identification and tracking of alloreactive T cell clones in Rhesus Macaques through the RM-scTCR-Seq platform.

U. Gerdemann, R. A. Fleming, J. Kaminski, C. McGuckin, X. Rui, J. F. Lane, P. Keskula, L. Cagnin, A. K. Shalek, V. Tkachev, L. S. Kean

The paper introduces RM-scTCR-Seq, a method for tracking T cell clones in Rhesus Macaques, and applies it to study GVHD.

bioRxiv · Oct 29, 2021Immunology

Spatiotemporal single-cell profiling of gastrointestinal GVHD reveals invasive and resident memory T cell states.

V. Tkachev, J. Kaminski, E. L. Potter, S. N. Furlan, A. Yu, D. J. Hunt, C. McGuckin, H. Zheng, L. Colonna, U. Gerdemann, J. Carlson, M. Hoffman, J. Olvera, C. English, A. Baldessari, , L. S. Kean

The paper uses SIVS and scRNA-seq to analyze T cell infiltration and residency in the GI tract during aGVHD, identifying genes associated with tissue invasiveness and TRM programming.

bioRxiv · Jul 20, 2020 · PreprintImmunology

IL2 enhances ex-vivo expanded regulatory T cell persistence after adoptive transfer

S. N. Furlan, K. Singh, C. Lopez, V. Tkachev, D. Hunt, J. Hibbard, K. M. Betz, B. R. Blazar, C. Trapnell, L. S. Kean

This study shows that adding IL2 to rapamycin increases the persistence of ex-vivo expanded regulatory T cells in non-human primates, doubling their numbers in peripheral blood.

bioRxiv · Oct 15, 2019Immunology