M. Muller

The antiviral protein Shiftless blocks p-body formation during KSHV infection.

This study identifies SHFL as a factor that disassembles p-bodies and inhibits KSHV infection by blocking PB formation and enhancing anti-viral cytokine expression.

Dynamic control of gene expression by ISGF3 and IRF1 duringIFNbeta and IFNgamma signaling

The paper shows that IFN-I and IFN-gamma produce distinct transcriptomes over time due to different roles of ISGF3 and IRF1 in enhancer activation and chromatin accessibility.

A novel interaction between the 5' untranslated region of the Chikungunya virus genome and Musashi RNA binding protein is essential for efficient virus genome replication.

This study identifies Musashi RNA binding proteins as essential for Chikungunya virus genome replication and suggests a potential therapeutic target.

Fast and artifact-free excitation multiplexing using synchronized image scanning

The paper introduces a device called Resonator for fast, artifact-free fluorescence imaging with multiple excitation wavelengths, demonstrating its use in monitoring light-induced dynamics and Ca2+ signaling.

Nonstructural protein 1 (nsp1) widespread RNA decay phenotype varies among Coronaviruses

This study compares the transcriptional targets and interactomes of four coronavirus nsp1 proteins, revealing virus-specific effects on host gene expression and protein interactions.

CXCR2 inhibition enables NASH-HCC immunotherapy

This study shows that combining CXCR2 inhibition with anti-PD1 therapy enhances immunotherapy response in NASH-HCC by reprogramming tumor-associated neutrophils.

Shiftless Restricts Viral Gene Expression and Influences RNA Granule Formation during KSHV lytic replication.

This paper identifies SHFL as an anti-viral protein that restricts KSHV replication by targeting viral gene expression and influencing RNA granule formation.

The m6A reader YTHDC2 is essential for escape from KSHV SOX-induced RNA decay

The paper shows that m6A modification recruits YTHDC2 to confer SOX resistance to IL-6 mRNA during KSHV lytic infection.

Technical advances in the development of zonation liver in vitro systems that incorporate localized Wnt activating signals

This study identifies methods to recreate a zonated liver microenvironment in vitro using Wnt signals and organoid models.

Canonical Wnt signalling is activated during BEC-to-hepatocyte conversion in vivo and modulates liver epithelial cell plasticity in hepatic organoids

This study investigates the role of canonical Wnt signaling in BEC-to-hepatocyte conversion during liver injury and shows its impact on epithelial cell plasticity in hepatic organoids.

The KSHV ORF20 Protein Interacts With The Viral Processivity Factor ORF59 And Promote Viral Reactivation.

This study identifies ORF20 as a key regulator of KSHV lytic reactivation by interacting with ORF59 and promoting vDNA replication and virion production.

3D synthetic microscaffolds promote homogenous expression of NANOG in mouse embryonic stem cells

This paper introduces 3D synthetic microscaffolds that enhance homogenous NANOG and OCT4 expression in mouse ESCs compared to 2D cultures.

Combining Crowdsourcing and Deep Learning to Assess Public Opinion on CRISPR-Cas9

The paper analyzes Twitter data on CRISPR-Cas9 using BERT and statistical methods to track public sentiment trends and link sentiment changes to specific events.

Mass spectrometry based immunopeptidomics leads to robust predictions of phosphorylated HLA class I ligands

The paper curates phosphorylated HLA-I ligands and develops a predictor for their interaction with HLA-I molecules.

Integrated Proteogenomic Deep Sequencing and Analytics Accurately Identify Non-Canonical Peptides in Tumor Immunopeptidomes

The paper develops an MS-based proteogenomic approach to identify non-canonical HLA peptides in tumors, finding hundreds of shared and tumor-specific peptides, including an immunogenic one from ABCB5.

C19ORF66 broadly escapes viral-induced endonuclease cleavage and restricts Kaposi Sarcoma Associated Herpesvirus (KSHV)

The paper identifies C19ORF66 as a transcript that escapes viral endonuclease cleavage and functions as a KSHV restriction factor.