Author

D. Heide

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:metabolomics· 1

Frequent Co-Authors

J. E. Barragan Avila· 2 shared M. Heikenwalder· 2 shared S. Gallage· 2 shared A. Ali· 1 shared A. Billeter· 1 shared A. I. Choudhury· 1 shared A. J. Rose· 1 shared C. S. Tran· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersCancer Biology

J. E. Barragan Avila

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Beneficial effects of intermittent fasting in NASH and subsequent HCC development are executed by concerted PPAR alpha and PCK1 action in hepatocytes

S. Gallage, A. Ali, J. E. Barragan Avila, N. Seymen, P. Ramadori, V. Joerke, L. Zizmare, J. Kosla, X. Li, E. Focaccia, S. Yousuf, T. Sijmonsma, M. Rahbari, K. S. Kommoss, A. Billeter, , M. Heikenwalder

This study shows intermittent fasting prevents NASH and HCC by PPAR alpha and PCK1 working together in liver cells.

bioRxiv · Oct 23, 2023 · PreprintCancer Biology

Ribosomal S6 kinase 1 regulates inflammaging via the senescence secretome

S. Gallage, E. E. Irvine, S. Pedroni, J. E. Barragan Avila, S. Khadayate, J. Pombo, S. Brookes, D. Heide, G. Dharmalingam, A. I. Choudhury, N. Herranz, S. Vernia, M. Heikenwalder, J. Gil, D. J. Withers

This study shows that S6K1 deletion reduces inflammation and immune infiltration in aged livers, suggesting it suppresses the inflammatory SASP, contributing to healthspan benefits.

bioRxiv · Oct 17, 2023Physiology

Comparison of HAV and HCV infections in vivo and in vitro reveals distinct patterns of innate immune evasion and activation

O. Colasanti, R. Burm, H.-E. Huang, T. Riedl, J. Traut, N. Gillich, T.-F. Li, L. Corneillie, S. Faure-Dupuy, O. Gruenvogel, D. Heide, J.-Y. Lee, C. S. Tran, U. Merle, M. Chironna, , V. Lohmann

This study compares HAV and HCV infections in vivo and in vitro, revealing that HAV induces an innate immune response via MDA5/LGP2 with limited protease-mediated suppression, while HCV activates TLR3 without TRIF cleavage.

bioRxiv · Nov 7, 2022 · PreprintImmunology