D. J. Marcinek

This study shows that Urolithin A improves mitochondrial function and cardiac health in aging and heart failure models.

This paper shows that Elamipretide improves ADP sensitivity in aged mitochondria by enhancing ADP uptake through the ANT, leading to improved muscle and heart function.

This study evaluates how age, sex, and biopsy methods affect mitochondrial respiration in mouse muscle fibers and introduces a protocol to reduce variability.

This study investigates how elamipretide affects age-related post-translational modifications in mouse heart proteins, finding that it reverses oxidative changes but not phosphorylation changes.

This study examines metabolic changes in aging mouse retina and eyecup, finding stable glucose and glutamine metabolism despite vision loss.

This study identifies increased proton leak in aged cardiomyocytes as a mechanism of cardiac dysfunction and shows that SS-31 reverses this by targeting ANT1 and mitochondrial function.