Author

D. J. Taylor

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Biophysics· 1 Cancer Biology· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

W. Huang· 3 shared A. Day· 1 shared A. N. Bortvin· 1 shared B. L. Bauer· 1 shared C.-C. Su· 1 shared D. R. Nair· 1 shared D. Schneidman-Duhovny· 1 shared E. W. Yu· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersCell Biology

W. Huang

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Genomic transfers help to decipher the ancient evolution of filoviruses and interactions with vertebrate hosts

D. J. Taylor, M. H. Barnhart

This paper resolves conflicts in filovirus evolution by analyzing paleoviral records, protein structures, and genomic transfers, revealing widespread functional co-option in vertebrate hosts.

bioRxiv · Nov 29, 2023Evolutionary Biology

Structural Basis for Regulated Assembly of the Mitochondrial Fission GTPase Drp1

K. Rochon, B. L. Bauer, N. A. Roethler, Y. Buckley, C.-C. Su, W. Huang, R. Ramachandran, M. S. K. Stoll, E. W. Yu, D. J. Taylor, J. A. Mears

This paper presents a cryo-EM structure of Drp1 dimer revealing conformational rearrangements that regulate its self-assembly and mitochondrial fission.

bioRxiv · Jun 22, 2023Cell Biology

Structure of a dominant negative mutant reveals a stalled intermediate in anthrax protective antigen pore maturation

H. Scott, W. Huang, S. Ganti, K. Zhang, N. Mehzabeen, A. Day, K. P. Battaile, S. Lovell, J. G. Bann, D. J. Taylor

The paper identifies a dominant negative mutation that stalls anthrax protective antigen pore maturation at an intermediate state, revealing structural features and a regulatory mechanism for pore formation.

Journal of Molecular Biology · May 1, 2022Peer-reviewedBiophysics

Super-immunity by broadly protective nanobodies to sarbecoviruses

Y. Xiang, W. Huang, H. Liu, Z. Sang, S. Nambulli, J. Tubiana, K. L. Williams, P. Duprex, D. Schneidman-Duhovny, I. A. Wilson, D. J. Taylor, Y. Shi

The paper isolates and characterizes ultrahigh-affinity nanobodies from a camelid immunized with SARS-CoV-2 RBD, showing broad sarbecovirus neutralization and structural insights.

bioRxiv · Dec 26, 2021 · PreprintMicrobiology

Local adaptation and archaic introgression shape global diversity at human structural variant loci

S. M. Yan, R. M. Sherman, D. J. Taylor, D. R. Nair, A. N. Bortvin, M. C. Schatz, R. C. McCoy

The paper identifies structural variants associated with local adaptation and archaic introgression in human populations using long-read sequencing and population genetic analysis.

bioRxiv · Jan 26, 2021Evolutionary Biology

SLX4IP-mediated telomere maintenance is essential for androgen receptor-independent castration-resistant prostate cancer

T. L. Mangosh, W. N. Awadallah, M. M. Grabowska, D. J. Taylor

This study shows that SLX4IP-mediated ALT is critical for AR-independent CRPC survival, as its inhibition leads to telomere shortening and senescence.

bioRxiv · Mar 31, 2020Cancer Biology