Artemisinin acts by inhibiting Plasmodium falciparum Ddi1, a retropepsin, resulting into the accumulation of ubiquitinated proteins
N. M. Onchieku, S. Kumari, R. Pandey, V. Sharma, M. Kumar, A. Deshmukh, I. Kaur, A. Mohmmed, D. Gupta, D. Kiboi, N. Gaur, P. Malhotra
This study shows that Artemisinin inhibits Plasmodium falciparum Ddi1, leading to ubiquitinated protein accumulation and impaired damage recovery.
bioRxiv · Jul 12, 2021 · PreprintCell Biology