A. Mohmmed

A dynamin-like protein in the human malaria parasite plays an essential role in mitochondrial homeostasis and fission during asexual blood stages

This study identifies PfDyn2, a dynamin-like protein in P. falciparum, essential for mitochondrial fission and homeostasis during asexual blood stages of malaria.

Characterization of Plasmodium falciparum RAP domain proteins-RAP291 and RAP070, and their association with ribosomal RNAs

This study characterizes two Plasmodium falciparum RAP domain proteins, showing they bind ribosomal RNAs and associate with the MSP-1 complex, and inhibit merozoite invasion.

Small-molecule inhibitors targeting prokaryotic ClpQ protease in Plasmodium display anti-malarial efficacies against blood and liver stages

This paper identifies small-molecule inhibitors of Plasmodium ClpQ protease that show anti-malarial activity against both blood and liver stages of malaria.

Dual role of an essential HtrA2/Omi protease in the human malaria parasite: maintenance of mitochondrial homeostasis and induction of apoptosis like cell death under cellular stress

This study identifies PfHtrA2's dual role in maintaining mitochondrial homeostasis and inducing apoptosis-like cell death in Plasmodium falciparum under stress.

Artemisinin acts by inhibiting Plasmodium falciparum Ddi1, a retropepsin, resulting into the accumulation of ubiquitinated proteins

This study shows that Artemisinin inhibits Plasmodium falciparum Ddi1, leading to ubiquitinated protein accumulation and impaired damage recovery.

A Plasmodium falciparum lysophospholipase regulates fatty acid acquisition for membrane biogenesis to enable schizogonic asexual division

This study identifies PfLPL3 as a key lysophospholipase in Plasmodium falciparum that facilitates fatty acid acquisition for membrane biogenesis, essential for asexual reproduction, and identifies potential anti-malarial inhibitors.

A lysophospholipase plays role in generation of neutral-lipids required for hemozoin formation in malaria parasite

This study identifies PfLPL1 as a lysophospholipase essential for generating neutral lipids required for hemozoin formation in malaria parasites, disrupting parasite growth and development.