Author

D. L. Keefe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

B. Xia· 1 shared C. Tian· 1 shared D. Barkley· 1 shared F. Wagner· 1 shared H. Chen· 1 shared H. Wang· 1 shared I. Yanai· 1 shared J. D. Boeke· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperEvolutionary Biology

B. Xia

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2 papers

Recent·Most cited

Comprehensive molecular features of polycystic ovary syndrome revealed by transcriptome analysis of oocytes and cumulus cells

J. Li, H. Chen, M. Gou, C. Tian, H. Wang, X. Song, D. L. Keefe, X. Bai, L. L. Liu

This study identifies altered gene expression and cell interactions in oocytes and cumulus cells of PCOS patients, highlighting dysregulated microtubule genes and transposable elements.

bioRxiv · Jan 30, 2021Cell Biology

Widespread transcriptional scanning in the testis modulates gene evolution rates

B. Xia, Y. Yan, M. Baron, F. Wagner, D. Barkley, M. Chiodin, S. Y. Kim, D. L. Keefe, J. P. Alukal, J. D. Boeke, I. Yanai

The paper maps gene expression in human spermatogenesis and finds that expressed genes have fewer germline mutations, suggesting transcriptional scanning reduces DNA damage and influences gene evolution rates.

bioRxiv · Jan 22, 2019Evolutionary Biology