Author

D. O'Sullivan

Primary ORCID profile (0000-0003-4442-3112 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

D. O'SullivaniD1 paper · Memorial Sloan Kettering Cancer Center

Biology Disciplines

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Genetic & Genomic Medicine· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

A. Ansari· 1 shared A. Brady· 1 shared A. Callaway· 1 shared A. Castoldi· 1 shared A. Donaldson· 1 shared A. Garrett· 1 shared A. Hadonou· 1 shared A. Innes· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

A. Ansari

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Classification of Variants of Reduced Penetrance in High Penetrance Cancer Susceptibility Genes: Framework for Genetics Clinicians and Clinical Scientists by CanVIG-UK (Cancer Variant Interpretation Group-UK)

Alice Garrett, Sophie Allen, Miranda Durkie, George J. Burghel, Rachel Robinson, Alison Callaway, Joanne Field, Bethan A. Frugtniet, Sheila Palmer-Smith, Jonathan Grant, Judith Pagan, Trudi McDevitt, Charlie F Rowlands, Terri Patricia McVeigh, Helen Hanson, , J. Williams

The paper develops a framework for classifying variants of reduced penetrance in cancer susceptibility genes to improve variant interpretation consistency.

Genetics in Medicine · Oct 24, 2024Peer-reviewedGenetic & Genomic Medicine

In macrophages fatty acid oxidation spares glutamate for use in diverse metabolic pathways required for alternative activation

N. van Teijlingen Bakker, L. Flachsmann, G. E. Carrizo, D. E. Sanin, S. Lawless, A. Castoldi, L. Monteiro, A. M. Kabat, M. Matsushita, F. Haessler, A. Patterson, R. Klein Geltink, D. O'Sullivan, E. L. Pearce, E. J. Pearce

This study shows that fatty acid oxidation in macrophages supports alternative activation by maintaining glutamate levels, and that glutamine metabolism compensates for FAO disruption.

bioRxiv · Apr 13, 2022 · PreprintImmunology

Comparison of SARS-CoV2 N gene real-time RT-PCR targets and commercially available mastermixes

J. R. Brown, D. O'Sullivan, R. P. Pereira, A. S. Whale, E. Busby, J. Huggett, K. Harris

The paper compares four RT-PCR mastermixes and three N gene assays for SARS-CoV-2 detection, finding the N2 assay most sensitive and Takara mastermix best at low detection limits.

bioRxiv · Apr 17, 2020Microbiology