Orthosteric-allosteric dual inhibitors of PfHT1 as selective anti-malarial agents
J. Huang, Y. Yuan, N. Zhao, D. Pu, Q. Tang, S. Zhang, S. Luo, X. Yang, N. Wang, Y. Xiao, T. Zhang, Z. Liu, T. Sakata-Kato, X. Jiang, N. Kato, , H. Yin
This paper develops dual orthosteric-allosteric inhibitors of PfHT1 that selectively target malaria parasites over human cells, showing potent activity against multidrug-resistant strains.
bioRxiv · Aug 25, 2020 · PreprintPharmacology & Toxicology