Author

D. Rudler

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Physiology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

A. Calkin· 1 shared A. Filipovska· 1 shared A. Jurrjens· 1 shared A. Nath· 1 shared A. W. Zhuang· 1 shared B. G. Drew· 1 shared C. Yang· 1 shared D. C. Henstridge· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperPhysiology

A. Calkin

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1 paper

Recent·Most cited

Skeletal Muscle Specific PolG Dysfunction Activates the Integrated Stress Response and Promotes a Cachexia like Phenotype

S. T. Bond, E. King, S. Walker, C. Yang, Y. Liu, K. Liu, A. W. Zhuang, A. Jurrjens, H. Fnag, A. Nath, L. E. Formosa, S. Ruiz Carmona, D. Rudler, N. Elahee Doomun, M. Inouye, , B. G. Drew

This study shows that muscle-specific PolG dysfunction causes mitochondrial dysfunction and cachexia by activating the mtISR and altering the mitochondrial folate cycle.

bioRxiv · Jun 2, 2024 · PreprintPhysiology