E. King

Skeletal Muscle Specific PolG Dysfunction Activates the Integrated Stress Response and Promotes a Cachexia like Phenotype

This study shows that muscle-specific PolG dysfunction causes mitochondrial dysfunction and cachexia by activating the mtISR and altering the mitochondrial folate cycle.

The endophytic fungus Serendipita indica alters auxin distribution in Arabidopsis thaliana roots through alteration of auxin transport and conjugation to promote plant growth

This study identifies how the endophytic fungus Serendipita indica promotes Arabidopsis growth by altering auxin transport and conjugation through GH3 genes and PIN2 expression.

Machine Learning Reveals Genetic Modifiers of the Immune Microenvironment of Cancer

This paper uses machine learning to identify genetic modifiers of the immune microenvironment in breast cancer, prioritizing LSP1 and TLR1 as potential therapeutic targets.

The Lion's Share: Implications of carnivore diet on endangered herbivores in Tsavo

The paper analyzes lion diet in Tsavo, Kenya, finding that lions disproportionately consume endangered hirola and Grevys zebra despite their low population sizes.

Ancient diversity in host-parasite interaction genes in a model parasitic nematode

The paper sequenced genomes of two parasitic nematodes, found high genetic diversity in host-interaction genes, and suggests long-term balancing selection maintains this diversity.

Discovery and characterization of cross-reactive intrahepatic antibodies in severe alcoholic hepatitis

This study identifies cross-reactive intrahepatic antibodies in severe alcoholic hepatitis that target both bacterial antigens and human proteins, suggesting a role in disease pathogenesis.

QC-GN2oMS2: a Graph Neural Net for High Resolution Mass Spectra Prediction.

The paper develops a graph neural network (GNN) that incorporates quantum chemical features to improve mass spectrum prediction, achieving better performance than baseline models.

Comparative genomics and transcriptomic response to root exudates of six rice root-associated Burkholderia sensu lato species

The paper compares the transcriptomic responses of six rice-associated Burkholderia sensu lato species to root exudates, finding species-specific adaptations rather than genus-based patterns.

Differential genetic strategies of Burkholderia vietnamiensis and Paraburkholderia kururiensis for root colonization of Oryza sativa ssp. japonica and ssp. indica, as revealed by Tn-seq

This study compares the genetic strategies of Burkholderia vietnamiensis and Paraburkholderia kururiensis for colonizing two rice subspecies using Tn-seq, revealing differences in fitness genes and host-specific adaptations.

Antimicrobial resistance in dairy slurry tanks: a critical point for measurement and control

This study identifies dairy slurry tanks as critical for antimicrobial resistance (AMR) prevalence and control, showing that 60 days of storage can reduce ARB spread by >99%.

Validation and Performance Comparison of Three SARS-CoV-2 Antibody Assays

This study validates and compares three SARS-CoV-2 antibody assays, finding high sensitivity and specificity with low cross-reactions and interferences.

Pairing two growth-based, high-throughput selections to fine tune conformational dynamics in oxygenase engineering

This paper introduces two growth-based selections in E. coli to engineer CHMO with improved thermostability and NADH cofactor specificity.

A growth-based, high-throughput selection platform enables remodeling of 4-hydroxybenzoate hydroxylase active site

This paper describes a growth-based selection platform for evolving 4-hydroxybenzoate hydroxylase to accept 3,4-dihydroxybenzoic acid, achieving higher catalytic efficiency.

Analyzing Human Movements - Introducing A Framework To Extract And Evaluate Biomechanical Data

The paper introduces a framework to classify movement data into normal and abnormal groups using machine learning, finding that some normal subjects exhibit abnormal movement patterns.