The YAP-TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress
C. Anerillas, K. Mazan-Mamczarz, A. B. Herman, R. Munk, G. K. Lam, M. Calvo-Rubio, A. Garrido, D. Tsitsipatis, J. L. Martindale, G. Altes, M. Rossi, Y. Piao, J. Fan, C.-Y. Cui, S. De, , M. Gorospe
This study identifies the YAP-TEAD pathway as a target for senolytic therapy, showing that inhibiting it induces apoptosis in senescent cells by increasing ER stress.
bioRxiv · Dec 18, 2022 · PreprintCell Biology