M. Kalia

Methotrimeprazine exerts antiviral and neuroprotective effects in Japanese encephalitis virus infection through activation of adaptive ER stress and autophagy

This study identifies Methotrimeprazine as a drug that reduces JEV infection through autophagy and ER stress, with neuroprotective and antiviral effects in a mouse model.

SARS-CoV-2 and its variants, but not Omicron, induces thymic atrophy and impaired T cell development

This study shows SARS-CoV-2 and its variants cause thymic atrophy and impair T cell development, with Omicron having a lesser effect than Delta.

Avobenzone, Guaiazulene and Tioxolone identified as potent autophagy inducers in a high-throughput image based screen for autophagy flux

The paper identifies Avobenzone, Guaiazulene, and Tioxolone as potent autophagy inducers through a high-throughput image-based screen using a GFP-LC3-RFP reporter system in A375 cells.

Ion dynamics at the energy-deprived tripartite synapse

This paper develops a biophysical model of a glutamatergic synapse to study synaptic failure during energy deprivation, showing that smaller extracellular space fractions increase vulnerability to ischemic damage.

Retinoic Acid Inducible Gene-I like Receptors Activate Snail and Slug to Limit RNA Viral Infections

The paper shows that RLRs activate Snail and Slug to limit RNA viral infections by regulating their transcription and enhancing the antiviral response.

Japanese encephalitis virus capsid protein interacts with non-lipidated MAP1LC3 on replication membranes and lipid droplets

This paper identifies a direct interaction between JEV capsid protein and non-lipidated MAP1LC3 on replication membranes and lipid droplets, independent of p62/SQSTM1.