PhysiologybioRxiv
A Mouse Model of the Protease Activated Receptor 4 (PAR4) Pro310Leu Variant has Reduced Platelet Reactivity
X. Han, E. A. Knauss, M. de la Fuente…·M. T. Nieman
This study creates a mouse model of the PAR4-P310L variant and shows reduced platelet reactivity to PAR4-activation peptide and thrombin, with no effect on ADP and convulxin responses.
DOI 10.1016/j.jtha.2024.03.004