Author

E. Bestion

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3 Ecology· 3 Evolutionary Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 7 Research Focus:ecology & biodiversity· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:development & morphogenesis· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:rat· 2

Frequent Co-Authors

P. Halfon· 4 shared S. MEZOUAR· 4 shared T. Decaens· 3 shared C. Ansaldi· 2 shared E. Raymond· 2 shared F. Bassissi· 2 shared G. Roth· 2 shared J.-P. Baudoin· 2 shared

Activity by Year

2017-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCancer Biology

P. Halfon

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Thermal environment and ecological interactions modulate the importance of evolution in response to warming

C. A. Faillace, S. Alvarez-Codesal, A. Garreau, E. Bestion, J. M. Montoya

The paper examines how evolution in response to warming affects consumer-resource dynamics in phytoplankton and zooplankton communities under different temperatures and ecological interactions.

bioRxiv · Sep 28, 2023 · PreprintEcology

Targeting PPT1 with ezurpimtrostat sensitives liver tumor to immunotherapy by switching cold into hot microenvironments

E. Bestion, M. Rachid, A. Tijeras-Raballand, G. Roth, T. Decaens, C. Ansaldi, S. MEZOUAR, E. Raymond, P. Halfon

This paper shows that inhibiting PPT1 with ezurpimtrostat enhances anti-PD-1 immunotherapy in liver cancer by converting cold to hot tumors.

bioRxiv · Jan 18, 2023 · PreprintCancer Biology

GNS561, a new autophagy inhibitor active against cancer stem cells in hepatocellular carcinoma and hepatic metastasis from colorectal cancer

S. Brun, J.-M. Pascussi, E. P. Gifu, E. Bestion, Z. Macek-Jilkova, G. Wang, F. Bassissi, S. Mezouar, J. Courcamberck, P. Merle, T. Decaens, J. Pannequin, P. Halfon, C. Caron de Fromentel

This study shows that GNS561, an autophagy inhibitor, effectively targets both cancer stem cells and bulk tumor cells in hepatocellular carcinoma and colorectal cancer metastasis.

bioRxiv · Dec 21, 2020Cancer Biology

GNS561 exhibits potent in vitro antiviral activity against SARS-CoV-2 through autophagy inhibition

P. Halfon, E. Bestion, K. Zandi, J. Andreani, J.-P. Baudoin, B. LA SCOLA, J.-L. Mege, S. Mezouar, R. F. Schinazi

This study shows GNS561, an autophagy inhibitor, has strong antiviral effects against SARS-CoV-2, both alone and in combination with remdesivir.

bioRxiv · Oct 6, 2020Pathology

GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions

S. BRUN, E. Raymond, F. Bassissi, Z. M. Jilkova, S. Mezouar, M. Rachid, M. Novello, J. Tracz, A. Hamai, G. Lalmanach, L. Vanderlynden, E. Bestion, R. Legouffe, J. Stauber, T. Schubert, , P. Halfon

This paper evaluates GNS561, a PPT1 inhibitor, showing its efficacy against HCC by modulating lysosomal functions and inducing cell death in vitro and in vivo.

bioRxiv · Sep 30, 2020Cancer Biology

Presence of a resident species aids invader evolution

J. Lachaplle, E. Bestion, E. E. Jackson, C.- E. Schaum

This study shows that the presence of a resident species can enhance invader fitness and adaptation in phytoplankton, with invaders showing lower extinction rates and broader environmental tolerance.

bioRxiv · May 19, 2020Evolutionary Biology

MetaConnect, a new platform for population viability modelling to assist decision makers in conservation and urban planning

S. Moulherat, E. Bestion, M. Baguette, M. Moulherat, S. C. F. Palmer, J. M. Travis, J. Clobert

MetaConnect is a new PVA platform that integrates landscape genetics and dispersal to assess population viability and inform conservation and urban planning decisions.

bioRxiv · Dec 30, 2019 · PreprintEcology

Metabolic traits predict the effects of warming on phytoplankton competition

E. Bestion, B. Garcia-Carreras, C.-E. Schaum, S. Pawar, G. Yvon-Durocher

The paper develops a model linking metabolic traits to phytoplankton competition outcomes under temperature changes, correctly predicting 71% of pairwise competition results.

bioRxiv · Dec 3, 2017Ecology