B. La Scola

This study revives a 600-year-old Acanthamoeba castellanii strain and its endosymbiont from coprolites, revealing their genomic features and survival mechanisms.

The paper analyzes SARS-CoV-2 mutations across 61,397 genomes to identify 'hyperfertile' mutations that spread widely, finding most did not predict new epidemic forms, with some in non-coding regions and stop codons.

This study shows SARS-CoV-2 spike proteins from four lineages induce hemagglutination, with Omicron requiring lower concentrations, and ivermectin inhibits this effect, suggesting therapeutic and safety implications.

This study sequenced Monkeypox virus genomes from infected patients, revealing APOBEC3-like editing, gene inactivation, and bacterial superinfections in lesions.

This paper investigates how SARS-CoV-2 affects Vγ9Vδ2 T cells in patients and shows that anti-BTN3A activation enhances their antiviral response.

The paper shows that Marseillevirus uses fully wrapped nucleosomes to densely package its genome, differing from eukaryotic chromatin organization.

The paper shows that the Omicron variant escapes neutralization by authorized mAbs, unlike previous variants, highlighting the need for updated protective measures for immunocompromised patients.

This study shows GNS561, an autophagy inhibitor, has strong antiviral effects against SARS-CoV-2, both alone and in combination with remdesivir.

This study identifies functional enzymes of the tricarboxylic acid cycle in Pandoravirus massiliensis, suggesting it may possess energy production capabilities and challenging traditional virus definitions.

This study shows SARS-CoV-2 infects monocytes and macrophages, inducing immunoregulatory cytokine secretion and M2-type transcriptional changes, leading to immunoparalysis in Covid-19 patients.

The paper describes the discovery of Yaravirus, a new amoeba virus with a near-complete ORFan genome, challenging existing DNA virus classifications.

This paper presents a high-content screening method for rapid and automated isolation of SARS-CoV-2 from clinical samples, achieving comparable isolation rates to traditional methods but with faster results and reduced contamination risks.

This study evaluates genome-resolved metagenomics for recovering giant virus genomes, showing success at high spike-in levels but highlighting the underdetection of most giant viruses.

This paper develops a high content screening (HCS) method for isolating Coxiella burnetii from clinical samples, showing higher sensitivity and efficiency compared to traditional shell-vial assays.

The paper identifies a metallo-beta-lactamase with dual beta-lactamase and ribonuclease activity in a giant virus and shows its RNase activity is not inhibited by common inhibitors.

This study investigates the composition of the Pandoravirus tegument, finding a cellulose-like layer and hypothesizing its synthesis may involve the host amoeba's machinery rather than viral genes.

The paper shows a virophage can expand its host range to new giant viruses, impacting giant virus production and host cell survival.

The paper transfers the MIMIVIRE defence system from Mimiviruses to E. coli to eliminate a plasmid by targeting tetracycline resistance sequences.