K. Lin

Reclassification of Genetic Variants in Patients with Hypertrophic Cardiomyopathy from the Sarcomeric Human Cardiomyopathy Registry (SHaRe)

The paper reclassifies genetic variants in HCM patients using a large registry, finding 10% of variants were reclassified, with most VUS unlikely to be causal.

A Molecular Image-based Explainable Artificial intelligence Framework Identifies Novel Candidate Antibiotics

This paper presents an explainable AI framework using molecular images to identify novel antibiotic candidates from FDA-approved drugs.

Canonical AREs are tumor suppressive regulatory elements in the prostate

This study identifies canonical AREs as tumor suppressive regulatory elements in prostate cancer, showing their reactivation can induce death in AR+ cancer cells and is linked to better prognosis.

Oblique Line Scan Illumination Enables Expansive, Accurate and Sensitive Single Protein Measurements in Solution and in Living Cells

This paper introduces Oblique Line Scan (OLS) illumination to enhance single-molecule tracking in living cells and solution, enabling high-throughput and sensitive protein dynamics measurements.

A "suicide" BCG strain provides enhanced immunogenicity and robust protection against Mycobacterium tuberculosis in macaques

This study develops a 'suicide' BCG strain that is safely eliminated in immunocompromised hosts but induces stronger immune responses and better protection against Mtb in macaques.

Development of an Engineered Mycobacterium tuberculosis Strain for a Safe and Effective Tuberculosis Human Challenge Model

This paper develops an engineered Mycobacterium tuberculosis strain with kill switches for a safe TB human challenge model, showing rapid clearance and low escape rates.

Immunotherapy for ovarian cancer is improved by tumor targeted delivery of a neoantigen surrogate

This study shows that delivering a neoantigen surrogate via Listeria monocytogenes combined with gemcitabine and anti-PD1 improves ovarian cancer treatment in mice.

Affinity hierarchies and amphiphilic proteins underlie the co-assembly of nucleolar and heterochromatin condensates

This study identifies an amphiphilic protein, Pitchoune, that mediates interactions between nucleoli and pericentromeric heterochromatin condensates during Drosophila development.

Reversing myeloid-derived suppressor cells mediated immunosuppression via p38α inhibition enhances immunotherapy efficacy in triple negative breast cancer

This study shows that p38α inhibition reduces immunosuppression by MDSCs and enhances immunotherapy in TNBC by decreasing CXCL1/CXCL2 expression.

Neutralization of SARS-CoV-2 BQ.1.1 and XBB.1.5 by Breakthrough Infection Sera from Previous and Current Waves in China

This study assesses neutralization of SARS-CoV-2 Omicron subvariants by sera from different vaccination and breakthrough infection cohorts, finding that BQ.1.1 and XBB.1.5 show strong neutralization evasion.

Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress

This study identifies Cdc73 as a Notch cofactor that protects T-ALL cells from DNA damage and mitochondrial stress by intersecting with Notch at chromatin to activate oncogenes and repair pathways.

A high-throughput platform for single-molecule tracking identifies drug interaction and cellular mechanisms

This paper introduces a high-throughput single-molecule tracking platform to study protein dynamics and drug interactions, identifying novel mechanisms and therapeutics.

Muscleblind-like proteins use modular domains to localize RNAs by riding kinesins and docking to membranes

The paper identifies how MBNL proteins localize RNAs via kinesin interaction and membrane docking, using a modular approach to study RNA-binding protein functions.

Dopamine D1-like receptor blockade and stimulation decreases operant responding for nicotine and food in male and female rats

This study examines how dopamine D1-like receptor agonists and antagonists affect nicotine and food intake and locomotor activity in male and female rats, finding no sex differences in their effects.

AT-752, a double prodrug of a guanosine nucleotide analog, inhibits yellow fever virus in a hamster model

This paper demonstrates that AT-752, a prodrug of a guanosine nucleotide analog, reduces YFV viremia and liver damage in hamsters and improves survival rates.

Oxalic acid binds to gustatory receptor Gr23a and inhibits feeding in the brown planthopper

The paper identifies oxalic acid as a ligand for the brown planthopper's gustatory receptor Gr23a, showing it inhibits feeding and is sensed by the receptor.

Single Cell Raman-Deuterium Isotope Probing for Drug Resistance of Elizabethkingia spp.

This study uses single cell Raman-DIP to rapidly determine antimicrobial susceptibility of Elizabethkingia spp. and confirms minocycline and levofloxacin as first-line treatments.

SPOP mutation confers sensitivity to AR-targeted therapy in prostate cancer by reshaping the androgen-driven chromatin landscape

This study shows that SPOP mutations in prostate cancer alter the chromatin landscape and AR-driven transcription, making tumors more responsive to AR-targeted therapies.

Protein-primed RNA synthesis in SARS-CoVs and structural basis for inhibition by AT-527

This paper identifies a protein-priming mechanism for SARS-CoV RNA synthesis and shows that AT-527 inhibits this process by targeting both NiRAN and RdRp domains.

Genetic models of latent tuberculosis in mice reveal differential control by adaptive immunity

This study develops genetic mouse models of latent tuberculosis, revealing that adaptive immunity differentially controls relapse depending on the model used.

Characterization of novel regulatory modules controlling leaf angle in maize

This study identifies novel regulatory modules involving ZmBEH1 and ZmBZR1 that control leaf angle in maize, offering new gene editing targets for improving plant architecture.

Advanced Retinal Imaging and Ocular Parameters of the Rhesus Macaque Eye

This study characterizes ocular biometrics and retinal function in rhesus macaques, finding similarities to human eyes, particularly in macular structure and cone photoreceptor function.

Pre-clinical studies of a recombinant adenoviral mucosal vaccine to prevent SARS-CoV-2 infection

This study evaluates mucosal adenovirus vaccines against SARS-CoV-2, showing that full-length spike antigen induces stronger neutralizing antibodies and T-cell responses compared to partial antigens in mice.

Proteasome activator PA200 maintains stability of histone marks during transcription and aging

This study shows that PA200 maintains histone mark stability during transcription and aging by promoting acetylation-dependent degradation of core histones.

Short-term stabilities of 21 amino acids in dried blood spots

This study assesses the short-term stability of 21 amino acids in dried blood spots under simulated global health conditions, finding that some amino acids degrade while others increase in concentration under high temperature and humidity.