D. A. Tuveson

p73 activates transcriptional signatures of basal lineage identity and ciliogenesis in pancreatic ductal adenocarcinoma

This study shows p73 activates basal lineage and ciliogenesis genes in PDAC, suggesting its role in lineage plasticity and tumor progression.

Internally-controlled and dynamic optical measures of functional tumor biology

This paper develops internally controlled optical reporters to quantitatively measure functional tumor biology, improving the accuracy of drug response assessment in vitro and in vivo.

Loss of p53 tumor suppression function drives invasion and genomic instability in models of murine pancreatic cancer

Loss of KRASG12D feedback regulation involving splicing factor SRSF1 accelerates pancreatic cancer

The paper shows that loss of SRSF1, a splicing factor, accelerates pancreatic cancer by disrupting homeostasis and enhancing KrasG12D-driven tumorigenesis.

Oncogenic KRAS engages an RSK1/NF1 complex in pancreatic cancer

This study identifies RSK1 as a KRASG12D-specific interactor in PDAC and shows RSK1 mediates negative feedback on wild-type KRAS.

DETECTION OF INCIPIENT PANCREATIC CANCER WITH NOVEL TUMOR-SPECIFIC ANTIBODIES IN MOUSE MODELS

This study develops tumor-specific antibodies for early detection of pancreatic cancer using PET imaging in mouse models, identifying two mAbs that bind to CEACAM6 variants in tumors.

Detection of Chemotherapy-Resistant Pancreatic Cancer Using a Glycan Biomarker

This paper identifies sTRA as a glycan biomarker for chemotherapy-resistant pancreatic cancer, showing its presence correlates with poor treatment response in multiple systems.

Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma

The paper uses isotope tracing to compare metabolism between cancer cells and fibroblasts in pancreatic tumors, identifying key metabolic dependencies in cancer cells.