Author

G. Biffi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 5 Research Focus:cell type annotation· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Approach:statistical model· 2

Frequent Co-Authors

D. A. Tuveson· 2 shared K. Miyabayashi· 2 shared A. Liston· 1 shared A. M. Darnell· 1 shared A. M. Westermark· 1 shared A. N. J. McKenzie· 1 shared A. N. Lau· 1 shared A. Peryt· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersCancer Biology

D. A. Tuveson

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Author profile →

7 papers

Recent·Most cited

Tissue-resident regulatory T cells exert dualistic anti-tumour and pro-repair function in the exocrine pancreas

J. Stockis, T. Yip, S. Raghunathan, C. Garcia, S. Lee, C. Simpson, S. Silvain, M. J. Schuijs, J. Araos, S. Png, G. Raddi, O. Bricard, T. Y. So, S. Mack, P. Papadopoulos, , T. Y. F. Halim

This study identifies a rare pancreatic tissue-resident regulatory T cell population that exhibits both anti-tumour and pro-repair functions in the exocrine pancreas.

bioRxiv · Feb 15, 2024 · PreprintImmunology

ERBB-activated myofibroblastic cancer-associated fibroblasts promote local metastasis of pancreatic cancer

G. Mucciolo, J. Araos Henriquez, S. Pinto Teles, J. S. Manansala, M. Jihad, W. Li, E. G. Lloyd, P. S. W. Cheng, G. Biffi

This study identifies ERBB signaling in myofibroblastic CAFs as a driver of local PDAC metastasis and suggests its potential as a therapeutic target.

Cancer Cell · Jan 1, 2024Peer-reviewedCancer Biology

Differential Activity of MAPK signalling Defines Fibroblast Subtypes in Pancreatic Cancer

L. Veghini, D. Pasini, P. Delfino, V. Corbo, E. Fiorini, F. Lupo, M. Bevere, C. Luchini, R. T. Lawlor, A. Scarpa, P. F.-Y. Cheung, J. T. Siveke, C. Vicentini, D. Filippini, S. L. D'Agosto, , R. Fang

This study identifies MAPK signalling as defining fibroblast subtypes in pancreatic cancer, linking MAPKhigh CAFs to poor prognosis and immune evasion.

bioRxiv · Oct 30, 2023Cancer Biology

Single-cell transcriptomic analysis of human pleura reveals stromal heterogeneity and informs in vitro models of mesothelioma

J. Obacz, R. Nibhani, T. S. Adams, J. C. Schupp, J. A. Valer, N. Veale, G. Aresu, A. S. Coonar, A. Peryt, G. Biffi, N. Kaminski, H. E. Francies, D. Rassl, M. Garnett, R. C. Rintoul, S. J. Marciniak

This study presents a single-cell transcriptomic atlas of human pleura, identifying stromal heterogeneity and informing in vitro models of mesothelioma.

bioRxiv · Dec 3, 2022 · PreprintCancer Biology

DETECTION OF INCIPIENT PANCREATIC CANCER WITH NOVEL TUMOR-SPECIFIC ANTIBODIES IN MOUSE MODELS

T. E. Oni, C. Bautista, J. R. Merrill, J. A. C. M. Goos, K. D. Rivera, K. Miyabayashi, G. Biffi, L. Garcia, D. Plenker, H. Patel, E. Elyada, M. Samaritano, K. H. Yu, D. J. Pappin, M. G. Goggins, , D. A. Tuveson

This study develops tumor-specific antibodies for early detection of pancreatic cancer using PET imaging in mouse models, identifying two mAbs that bind to CEACAM6 variants in tumors.

bioRxiv · Sep 10, 2020 · PreprintCancer Biology

Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma

A. N. Lau, Z. Li, L. V. Danai, A. M. Westermark, A. M. Darnell, R. Ferreira, V. Gocheva, S. Sivanand, E. C. Lien, K. M. Sapp, J. R. Mayers, G. Biffi, C. R. Chin, S. M. Davidson, D. A. Tuveson, , M. Vander Heiden

The paper uses isotope tracing to compare metabolism between cancer cells and fibroblasts in pancreatic tumors, identifying key metabolic dependencies in cancer cells.

bioRxiv · Mar 9, 2020Cancer Biology

Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation

T. Somerville, G. Biffi, J. Dassler-Plenker, K. Miyabayashi, Y. Xu, D. Maia-Silva, O. Klingbeil, O. Demerdash, M. Egeblad, D. Tuveson, C. Vakoc

This study shows that squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation by converting pancreatic stellate cells into inflammatory CAFs via TP63-dependent mechanisms.

bioRxiv · Nov 6, 2019Cancer Biology