E. Derivery

Design of intrinsically disordered region binding proteins

The paper designs proteins that bind intrinsically disordered regions with high affinity and specificity across diverse targets.

Multispectral live-cell imaging with uncompromised spatiotemporal resolution

The paper introduces a multispectral imaging approach for live-cell imaging, enabling accurate unmixing of low signal-to-noise ratio data at video rates.

A force-sensitive mutation reveals a spindle assembly checkpoint-independent role for dynein in anaphase progression

This study identifies a mutation in dynein that causes mitotic spindle arrest independent of the spindle assembly checkpoint, revealing a load-dependent role in anaphase progression.

Elongator is a microtubule polymerase selective for poly-glutamylated tubulin

This paper identifies Elongator's role in stabilizing microtubules by selectively binding polyglutamylated tubulin, contributing to cell fate determination during asymmetric division.

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes

This study shows ANXA11 biomolecular condensates couple protein and lipid phase states on lysosomal membranes through interactions with ALG2 and CALC.

HEATR5B associates with dynein-dynactin and selectively promotes motility of AP1-bound endosomal membranes

This study identifies HEATR5B as a novel dynein-dynactin interactor that promotes AP1-bound endosomal membrane motility and Golgi transport in human and Drosophila cells.

Structure of the Commander endosomal trafficking complex linked to X-linked intellectual disability/Ritscher-Schinzel syndrome

The paper presents the structural model of the Commander endosomal trafficking complex, identifies disease-causing mutations, and reveals its molecular function in trafficking.

De novo design of modular peptide binding proteins by superhelical matching

This paper introduces a method to design modular peptide binding proteins that bind repeating peptide sequences with high specificity and affinity.

Induction of cortical Par complex polarity by designed proteins causes cytoskeletal symmetry breaking in unpolarized mammalian cells

The paper shows that inducing Par complex cortical polarity with designed proteins causes cytoskeletal symmetry breaking and asymmetric cell division features in unpolarized cells.

Fibrinogen anchors for micropatterning of active proteins and subcellular receptor relocalisation

This paper introduces a method using fibrinogen as an anchor to improve protein micropatterning efficiency and activity, enabling precise control of cell shape and receptor distribution.

The Arp1/11 Minifilament of Dynactin Primes the Endosomal Arp2/3 Complex

The paper shows that the WASH complex interacts with Dynactin and uncaps it, allowing the Arp1/11 minifilament to prime Arp2/3 complex-mediated actin branching at endosomes.

Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology

The paper shows that circadian protein rhythms are compensated by ion transport to maintain osmotic balance and cellular function in mammalian cells and cardiomyocytes.

Self-repair protects microtubules from their destruction by molecular motors

The paper investigates how molecular motors affect microtubule stability and discovers a self-repair mechanism that counteracts motor-induced damage.