Author

E. Giff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:ChIP-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. J. Patel· 2 shared C. J. Lee· 2 shared C. R. Antonescu· 2 shared D. Zheng· 2 shared E. W. P. Wong· 2 shared J. Yan· 2 shared M. A. Miranda-Roman· 2 shared P. Chi· 2 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

A. J. Patel

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2 papers

Recent·Most cited

PRC2 Inactivating Mutations in Cancer are Synthetic Lethal with DNMT1 Targeted Therapy via Enhanced Viral Mimicry

A. J. Patel, S. Warda, J. L. V. Maag, R. Misra, M. A. Miranda-Roman, M. R. Pachai, C. J. Lee, D. Li, N. Wang, G. Bayshtok, Y. Meng, E. W. P. Wong, J. Yan, E. Giff, M. B. Pappalardi, , P. Chi

This paper identifies synthetic lethality between PRC2 inactivation and DNMT1 inhibition in MPNST, showing enhanced cytotoxicity through retrotransposon activation and innate immune signaling.

bioRxiv · May 28, 2022 · PreprintCancer Biology

Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert tumor microenvironment and confers resistance to immunotherapy

J. Yan, Y. Chen, A. J. Patel, S. Warda, B. G. Nixon, E. W. P. Wong, M. A. Miranda-Roman, C. J. Lee, N. Yang, Y. Wang, J. Sher, E. Giff, F. Tang, E. Khurana, S. Singer, , P. Chi

This study shows that PRC2 inactivation in tumors creates an immune-desert microenvironment, leading to resistance to immunotherapy and suggests strategies to reverse this effect.

bioRxiv · May 27, 2022 · PreprintCancer Biology