Dysregulated expression of Hoxa1 isoforms in hematopoietic stem and progenitor cells causes myelodysplastic syndromes.
S. Y. Tan, C. Joseph, M. L. Sobah, A. Chalk, K. Schleibs, S. Lee, G. Tjin, S. Chugh, X. Mo, C. Grace, J. Q. Truong, M. F. Smeets, K. Rice, M. Parker, A. Unnikrishnan, , L. Purton
This study shows that dysregulated Hoxa1 isoforms in hematopoietic stem and progenitor cells cause myelodysplastic syndromes and provide mouse models for disease progression.
bioRxiv · Apr 24, 2023 · PreprintCancer Biology