Cancer mutations rewire the RNA methylation specificity of METTL3-METTL14
C. Zhang, L. Tunes, M.-H. Hsieh, P. Wang, A. Kumar, B. B. Khadgi, Y.-Y. Yang, K. A. Doxtader, E. Herrell, O. Koczy, R. Setlem, X. Zhang, B. M. Evers, Y. Wang, C. Xing, , Y. Nam
The paper shows that a cancer mutation in METTL14 changes RNA methylation specificity, promoting oncogenesis by altering gene expression without increasing global m6A levels.
bioRxiv · Mar 16, 2023 · PreprintBiochemistry