E. Koch

Effects of Polyphosphate metabolism Mutations on Biofilm, Capsule Formation and Virulence Traits in Hypervirulent ST23 Klebsiella pneumoniae SGH10

This study examines how mutations in polyphosphate metabolism affect biofilm, capsule formation, and virulence in hypervirulent Klebsiella pneumoniae using a model host.

Recurrent mutation in the ancestry of a rare variant

The paper develops a statistical model to account for recurrent mutations in the ancestry of rare variants and applies it to human SNP data to explain differences in site-frequency spectra across mutation rates.

Correlation of biomechanics and cancer cell phenotype by combined Brillouin and Raman spectroscopy of U87-MG glioblastoma cells

This study uses Brillouin and Raman spectroscopy to correlate biomechanical properties with biochemical composition and cell phenotype in U87-MG glioblastoma cells.

Longitudinal effects of using and discontinuing CNS medications on cognitive functioning

This study examines how long-term use and discontinuation of CNS medications affect cognitive performance over 15 years in healthy adults.

Maintenance of adaptive dynamics and no detectable load in a range-edge out-crossing plant population

The paper examines a range-edge population of Arabidopsis lyrata ssp petraea and finds it maintains adaptive dynamics and no detectable fitness load despite genetic drift and increased genomic burden of deleterious mutations.

Polygenic adaptation of rosette growth in Arabidopsis thaliana populations

This study investigates the genetic and environmental factors influencing growth rate variation in Arabidopsis thaliana, finding polygenic adaptation and environmental plasticity as key drivers.

An insulin, AMPK, and steroid hormone-mediated metabolic switch regulates the transition between growth and diapause in C. elegans

The paper shows that insulin, AMPK, and steroid hormone pathways regulate metabolic shifts during growth and diapause in C. elegans by altering enzyme ratios in central metabolic pathways.

Restoring ancestral phenotypes by reduction of plasticity is a general pattern in gene expression during adaptation to different stressors in Tribolium castaneum

The paper shows that during adaptation to different stressors in Tribolium castaneum, gene expression shifts toward ancestral levels, with reduced plasticity and increased mean expression.

The effects of demography and genetics on the neutral distribution of quantitative traits

This paper develops a neutral model for quantitative trait variation using a coalescent approach, showing how deviations from normality depend on demography and genetic parameters.