Author

M. Hoffman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 2 Biophysics· 1 Cancer Biology· 1 Zoology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:non-human primate· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. Panoskaltsis-Mortari· 2 shared A. Yu· 2 shared B. R. Blazar· 2 shared C. McGuckin· 2 shared D. J. Hunt· 2 shared H. Zheng· 2 shared L. Colonna· 2 shared L. S. Kean· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

A. Panoskaltsis-Mortari

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Single-molecule acceptor rise time (smART) FRET for nanoscale distance sensitivity

J. Guo, X. Chen, P. Manna, X. Lin, M. N. Scott, W. J. Chen, M. Hoffman, B. Zhang, G. S. Schlau-Cohen

This paper introduces smART FRET, a method that improves distance sensitivity in single-molecule studies by using acceptor rise time, enabling both closer and longer distance measurements with higher precision.

bioRxiv · Mar 15, 2023 · PreprintBiophysics

Evolutionarily conserved effects of Notch signaling drive intestinal graft-versus-host disease in mice and non-human primates

V. Tkachev, A. Vanderbeck, E. Perkey, S. N. Furlan, C. McGuckin, D. Gomez Atria, U. Gerdemann, X. Rui, J. Lane, D. J. Hunt, H. Zheng, L. Colonna, M. Hoffman, A. Yu, S. Kelly, , I. Maillard

This study shows that Notch signaling, specifically through DLL4, promotes intestinal GVHD in mice and non-human primates by enhancing effector T-cell infiltration and reducing regulatory T-cell activity.

bioRxiv · Apr 23, 2022 · PreprintImmunology

Spatiotemporal single-cell profiling of gastrointestinal GVHD reveals invasive and resident memory T cell states.

V. Tkachev, J. Kaminski, E. L. Potter, S. N. Furlan, A. Yu, D. J. Hunt, C. McGuckin, H. Zheng, L. Colonna, U. Gerdemann, J. Carlson, M. Hoffman, J. Olvera, C. English, A. Baldessari, , L. S. Kean

The paper uses SIVS and scRNA-seq to analyze T cell infiltration and residency in the GI tract during aGVHD, identifying genes associated with tissue invasiveness and TRM programming.

bioRxiv · Jul 20, 2020 · PreprintImmunology

Phylogenetic, population genetic, and morphological analyses reveal evidence for one species of Eastern Indigo Snake (Drymarchon couperi)

B. Folt, J. Bauder, S. Spear, D. Stevenson, M. Hoffman, J. Oaks, C. Jenkins, D. Steen, C. Guyer

The paper rejects the two-species hypothesis for Drymarchon couperi by showing phylogenetic, population genetic, and morphological evidence supports a single species.

bioRxiv · Oct 26, 2018 · PreprintZoology

Subclonal architecture, evolutionary trajectories and patterns of inheritance of germline variants in pediatric glioblastoma

M. Hoffman, A. H. Gillmor, D. J. Kunz, M. J. Johnston, A. Nikolic, K. Karta, J. King, K. Ellestad, N. H. Dang, F. M. Cavalli, M. M. Kushida, F. J. Coutinho, B. Luu, Y. Ma, A. J. Mungall, , M. Gallo

This study examines genetic heterogeneity and evolutionary patterns in pediatric glioblastoma using whole-genome sequencing of germline-tumor pairs, revealing subclonal architecture and complex inheritance mechanisms.

bioRxiv · Oct 12, 2018Cancer Biology