CDK12/CDK13 inhibition disrupts a transcriptional program critical for glioblastoma survival
S. Lier, S. O. Lund, A. Lipsa, K. B. M. Frauenknecht, I. D. Rein, P. Jain, A. Lang, E. Lang, N. Meyer, A. Datta, S. Anand, G. Nesse, R. J. Forstrom, A. Klungland, J. E. Rinholm, , D. P. Pandey
This study shows that inhibiting CDK12 and CDK13 reduces glioma cell proliferation and migration, and disrupts transcription and cell cycle progression in glioblastoma.
bioRxiv · Jul 14, 2023Cancer Biology