A. Datta

A Cell-Permeable Fluorescent Probe Reveals Temporally Diverse PI(4,5)P2 Dynamics Evoked by Distinct GPCR Agonists in Neurons

This paper develops a fluorescent probe to track PI(4,5)P2 dynamics in neurons, revealing that hallucinogenic ligands at the 5-HT2A receptor cause slower initial PI(4,5)P2 depletion compared to non-hallucinogenic ligands.

Using machine learning to dissect host kinases required for Leishmania internalization and development

This study uses a kinase inhibitor screen to identify host kinases involved in Leishmania uptake and survival in macrophages, revealing both known and novel regulators.

Naphthalimide-based, Single-Chromophore, Ratiometric Fluorescent Sensor for Tracking Intracellular pH

The paper introduces a novel ratiometric fluorescent sensor, TRapH, for tracking intracellular pH in living cells and demonstrates its use in monitoring pH dynamics induced by a synthetic H+-transporter.

Pooled screening for CAR function identifies novel IL13Rα2-targeted CARs for treatment of glioblastoma

The paper identifies novel IL13Rα2-targeted CARs with improved anti-glioblastoma efficacy using a pooled screening platform.

The Candida auris Hog1 MAP kinase is essential for the colonization of murine skin and intradermal persistence

This study identifies Hog1 MAP kinase as essential for Candida auris skin colonization and intradermal persistence through RNA-seq and phenotypic analyses.

Effects of sampling methodology on phenology indices: insights from sites across India and modelling

This study examines how sampling methods affect phenology indices in tropical trees across India and provides recommendations for future research.

CDK12/CDK13 inhibition disrupts a transcriptional program critical for glioblastoma survival

This study shows that inhibiting CDK12 and CDK13 reduces glioma cell proliferation and migration, and disrupts transcription and cell cycle progression in glioblastoma.

MAPK/ERK Activation in Macrophages Promotes Leishmania Internalization and Pathogenesis

This study shows that MAPK/ERK signaling in macrophages promotes Leishmania uptake and disease severity, with trametinib reducing infection in mice.

The Src and Abl family kinases activate the Spleen Tyrosine Kinase to maximize phagocytosis and Leishmania infection

This study shows that Src and Abl family kinases activate SYK to enhance Leishmania uptake by macrophages, leading to increased disease in mice.

Impact of galvanic vestibular stimulation electrode current density on brain current flow patterns: Does electrode size matter?

This study simulates brain current flow patterns with different electrode sizes to explain clinical effects of galvanic vestibular stimulation.

How to Assemble a Scale-Invariant Gradient

The paper demonstrates that protein gradients in cells are scale-invariant, determined by cell geometry rather than diffusion or transport parameters.

Decisive Role of Polymer-BSA Interactions in Biofilm Substrates on Philicity and EPS Composition

This study investigates how polymer-BSA interactions affect biofilm philicity and EPS composition by analyzing bacterial growth on different polymers with and without BSA conditioning.

Control of filament length by a depolymerizing gradient

The paper investigates length-dependent depolymerization as a mechanism for controlling filament length, analyzing linear and exponential gradient scenarios and comparing results to experimental data.

Advanced Biophysical Model to Capture Channel Variability for EQS Capacitive HBC

This paper develops a biophysical model to analyze path loss variability in capacitive HBC channels by investigating inter-device coupling and fringe field effects using FEM simulations and measurements.

Patterns of roost site use by Asian hornbills and implications for seed dispersal

This study tracks roost site use by hornbills in northeast India and finds that roost locations influence seed dispersal patterns, with seeds dispersed at roosts traveling farther than those at non-roost sites.

Comprehensive Live-cell Imaging Analysis of Cryptotanshinone and Synergistic Drug-Screening Effects in Various Human and Canine Cancer Cell Lines

The paper evaluates the anticancer effects of Cryptotanshinone (CT) and synergistic drug combinations in human and canine cancer cell lines using live-cell imaging.

Optimization of interferential stimulation of the human brain with electrode arrays

This paper optimizes interferential stimulation (IFS) using electrode arrays to achieve focal brain stimulation, showing it can be more focal than conventional HD-TES but with lower intensity.

Persistent loss of biologically-rich tropical forests in the Indian Eastern Himalaya

The paper assesses deforestation in a Reserved Forest in the Indian Eastern Himalaya, identifying illegal logging as the main driver and highlighting governance challenges.

Factors affecting the survival of tree seedlings following shifting cultivation in the Eastern Himalaya

The paper examines how seedling survival varies with species and site conditions in a shifting cultivation landscape in the Eastern Himalaya.

Realistic vOlumetric-Approach to Simulate Transcranial Electric Stimulation -- ROAST -- a fully automated open-source pipeline

ROAST is an open-source pipeline for individualized TES modeling that automates segmentation, electrode placement, and FEM solving, showing comparable results to commercial tools.

Fibroblast-derived HGF drives acinar lung cancer cell polarization through integrin-dependent RhoA-ROCK1 inhibition.

The paper shows fibroblast-derived HGF induces correct polarity and acinar morphogenesis in lung cancer cells by inhibiting RhoA-ROCK1 via integrin and c-Src signaling.