Author

E. Llewellyn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 4 Approach:experimental assay· 4 Organism:virus· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:microscopy & imaging analysis· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

J. Chen· 5 shared S. A. Darst· 5 shared E. A. Campbell· 4 shared B. Malone· 3 shared E. T. Eng· 3 shared P. D. B. Olinares· 3 shared B. T. Chait· 2 shared D. E. Shaw· 2 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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5 shared papersBiophysics

J. Chen

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Author profile →

6 papers

Recent·Most cited

An ensemble of interconverting conformations of the elemental paused transcription complex creates regulatory options

J. Y. Kang, T. V. Mishanina, Y. Bao, J. Chen, E. Llewellyn, J. Liu, S. A. Darst, R. Landick

This study defines an interconverting ensemble of ePEC states using cryo-EM and biochemical analysis, showing that ePECs occupy pre- or half-translocated states without always swiveling.

bioRxiv · Sep 11, 2022Biochemistry

Ensemble cryo-electron microscopy reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex

J. Chen, Q. Wang, B. Malone, E. Llewellyn, Y. Pechersky, K. Maruthi, E. T. Eng, J. K. Perry, E. A. Campbell, D. E. Shaw, S. A. Darst

This study uses cryo-EM and simulations to identify four conformational states of the nsp13 helicase in the SARS-CoV-2 RTC, revealing an allosteric mechanism for switching between RNA synthesis and backtracking.

bioRxiv · Nov 10, 2021 · PreprintBiophysics

Structural basis for backtracking by the SARS-CoV-2 replication-transcription complex

B. Malone, J. Chen, Q. Wang, E. Llewellyn, Y. J. Choi, P. D. B. Olinares, X. Cao, C. Hernandez, E. T. Eng, B. T. Chait, D. E. Shaw, R. Landick, S. A. Darst, E. A. Campbell

This paper shows that SARS-CoV-2 RdRp undergoes backtracking, which may aid proofreading and antiviral resistance.

bioRxiv · Mar 13, 2021Biochemistry

Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex

J. Chen, B. Malone, E. Llewellyn, M. Grasso, P. M. M. Shelton, P. D. B. Olinares, K. Maruthi, E. T. Eng, H. Vatandaslar, B. Chait, T. Kapoor, S. A. Darst, E. A. Campbell

The paper presents cryo-EM structures of the SARS-CoV-2 holo-RdRp complex with nsp13 helicase, revealing interactions and a new therapeutic target.

Cell · Sep 1, 2020Peer-reviewedBiophysics

Structural basis for transcription complex disruption by the Mfd translocase

J. Y. Kang, E. Llewellyn, J. Chen, P. D. B. Olinares, J. Brewer, B. T. Chait, E. A. Campbell, S. A. Darst

The paper uses cryo-EM to visualize Mfd interacting with stalled RNA polymerase complexes, revealing its mechanism for initiating transcription-coupled repair.

bioRxiv · Aug 12, 2020Biophysics

Biofilm Formation by Staphylococcus aureus is Triggered by a Drop in the Levels of the Second Messenger cyclic-di-AMP

A. K. Syed, C. R. Vickery, T. Lenhart, E. Llewellyn, S. Walker, R. Losick

This study identifies a drop in cyclic-di-AMP levels as the trigger for biofilm formation in Staphylococcus aureus, mediated through reduced agr expression.

bioRxiv · Jan 31, 2020 · PreprintMicrobiology