Author

J. Castle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1

Frequent Co-Authors

A. Calista· 1 shared A. Ishaq· 1 shared A. Joshi· 1 shared A. Prasad· 1 shared B. Dadpey· 1 shared B. Pizer· 1 shared D. A. Luan· 1 shared D. Hicks· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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1 shared paperCell Biology

A. Calista

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mild uncoupling of mitochondria synergistically enhances senolytic specificity and sensitivity of BH3 mimetics

E. Fielder, A. Ishaq, E. Low, J. Laws, A. Calista, J. Castle, T. von Zglinicki, S. Miwa

This study shows that mild mitochondrial uncoupling enhances the senolytic effectiveness of BH3 mimetics in vitro and in vivo by targeting senescent cell vulnerabilities.

bioRxiv · Aug 23, 2023 · PreprintCell Biology

Adipocyte-secreted IL-6 sensitizes macrophages to IL-4 signaling

D. A. Luan, B. Dadpey, J. Zaid, P. E. Bridge-Comer, J. H. DeLuca, W. Xia, J. Castle, S. M. Reilly

The paper shows that adipocyte-secreted IL-6 enhances macrophage sensitivity to IL-4 signaling through STAT3 activation and Il4ra expression.

bioRxiv · Jul 19, 2022Immunology

Medulloblastoma Group 3 and 4 Tumors Comprise a Clinically and Biologically Significant Expression Continuum Reflecting Human Cerebellar Development

D. Williamson, E. C. Schwalbe, D. Hicks, K. A. Aldinger, J. Lindsey, S. Crosier, S. Richardson, J. Goddard, R. Hill, J. Castle, Y. Grabovska, J. Hacking, B. Pizer, S. B. Wharton, T. S. Jacques, , S. C. Clifford

The paper shows medulloblastoma Group3 and Group4 tumors form a transcriptional continuum linked to cerebellar development, with prognostic and molecular implications.

bioRxiv · Jun 9, 2022Cancer Biology

TISMorph: A tool to quantify texture, irregularity andspreading of single cells

E. Alizadeh, W. Xu, J. Castle, J. Foss, A. Prasad

TISMorph quantifies cell shape features like texture, irregularity, and spreading to classify osteosarcoma cell lines treated with cytoskeletal drugs.

bioRxiv · Nov 21, 2018Bioengineering