R. Goldstone

This paper shows that combining RASG12C(ON) and SHP2 inhibitors can make cold lung tumors responsive to immune checkpoint blockade by altering the tumor microenvironment and enhancing anti-tumor immunity.

The paper identifies KRAS-induced COX-2 as a driver of immunotherapy resistance in lung cancer through CRISPR/Cas9 screening and shows targeting COX-2 enhances immune checkpoint blockade efficacy.

This study identifies SIGNR1's role in promoting immune dysfunction during systemic candidiasis by modulating neutrophil lifespan through T cell-derived histones and G-CSF.

This study identifies immunogenomic features predicting response to immune checkpoint blockade in colorectal cancer, showing that high clonality and immune escape mechanisms are more important than mutational burden.