Targeted Reactivation of X-linked Endogenous FOXP3 Gene from X-chromosome Inactivation in Human Female Breast Cancer Cells
X. Cui, Z. Xu, S. Wang, X. Li, E. Stringer-Reasor, S. Bea, L. Zeng, D. Zhao, R. Liu, L. S. Qi, L. Wang
This paper develops a CRISPRi/a approach to reactivate FOXP3 and silence XIST from XCI in human breast cancer cells, showing enhanced epigenetic changes and therapeutic potential.
bioRxiv · Aug 14, 2021Cancer Biology