Mouse mammary tumor virus is implicated in severity of colitis and dysbiosis in the IL-10-/- mouse model of inflammatory bowel disease
H. Armstrong, M. Rahbari, H. Park, D. Sharon, A. Thiesen, N. Hotte, N. Sun, H. Syed, H. Abofayed, W. Wang, K. Madsen, E. Wine, A. Mason
This study investigates the role of mouse mammary tumor virus (MMTV) in colitis and dysbiosis in IL-10-/- mice, finding that MMTV contributes to disease severity and that antiretroviral therapy reduces MMTV load and improves symptoms.
bioRxiv · Jan 26, 2023Microbiology