Ehud Y. Isacoff

The paper develops a photoswitchable antagonist for the dopamine D1 receptor to enable precise temporal and spatial control of receptor activity in the brain.

The paper shows that weakening synaptic transmission in Drosophila larvae leads to transcriptional changes that increase presynaptic excitability.

This study identifies a pre-active intermediate in GPCR activation and shows how dimer interactions influence signaling efficacy and functional diversity.

This study identifies structural features determining G protein coupling specificity at a class A GPCR using a Gi-biased agonist.

The paper shows that synaptic release probability varies across synapses but remains constant overall due to balanced facilitation and depression.

The paper shows that synaptic weakening in Drosophila motor neurons is compensated by increased firing and reduced inhibition, maintaining locomotion.

This study uses smFRET to analyze GluN1 conformational changes in NMDA receptors with different GluN2 subunits, revealing subtype-specific allosteric control mechanisms.

This paper develops a chemogenetic method to irreversibly activate K2P channels, enabling studies of their function and potential therapeutic applications.

The paper proposes a step-wise activation model for metabotropic glutamate receptor subtype 5, supported by structural and fluorescence imaging data of different activation states.

This paper demonstrates a chemical-optogenetic approach that restores high-sensitivity motion vision in an IRD mouse model using a multi-branched photoswitch.

The paper introduces a method for high-resolution multi-cell optogenetic targeting using temporally focused light shaping in Drosophila and zebrafish larvae.