Cardiac-targeted rAAV5-S100A1 gene therapy protects against adverse remodeling and contractile dysfunction in post-ischemic hearts
D. Kehr, J. Salatzki, B. Krautz, K. Varadi, J. Birkenstock, P. Schlegel, E. Gao, W. J. Koch, J. Riffel, F. Andre, K. Peppel, H. A. Katus, N. Frey, M. Busch, H. Pfannkuche, , P. Most
This study demonstrates that cardiac-targeted rAAV5-S100A1 gene therapy reduces adverse remodeling and improves contractile function in post-ischemic hearts in pigs and mice.
bioRxiv · Mar 3, 2023 · PreprintPathology