Author

W. J. Koch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Pathology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

E. Gao· 3 shared A. Jungmann· 2 shared D. Kehr· 2 shared H. A. Katus· 2 shared J. Birkenstock· 2 shared J. Ritterhoff· 2 shared K. Varadi· 2 shared N. Frey· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersPharmacology & Toxicology

E. Gao

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivMar 4, 2023

S100A1ct: a synthetic peptide derived from human S100A1 protein improves cardiac contractile performance and survival in pre-clinical heart failure models

D. Kehr, J. Ritterhoff, M. Glaser…·P. Most

This paper develops a synthetic peptide S100A1ct that improves cardiac function and survival in heart failure models by enhancing Ca2+ cycling and targeting SERCA2a and RyR2.

DOI 10.1161/circulationaha.123.066961

humanexperimental assay

𝕏 PostBluesky

PathologybioRxivPreprintMar 3, 2023

Cardiac-targeted rAAV5-S100A1 gene therapy protects against adverse remodeling and contractile dysfunction in post-ischemic hearts

D. Kehr, J. Salatzki, B. Krautz…·P. Most

This study demonstrates that cardiac-targeted rAAV5-S100A1 gene therapy reduces adverse remodeling and improves contractile function in post-ischemic hearts in pigs and mice.

DOI 10.1101/2023.03.03.529004

humanmouse

𝕏 PostBluesky

PhysiologybioRxivJun 18, 2020

A Peptide of the Amino-Terminus of GRK2 Induces Hypertrophy and Yet Elicits Cardioprotection after Pressure Overload

S. M. Schumacher, K. M. Bledzka, J. Grondolsky…·W. J. Koch

This study shows that a GRK2 amino-terminal peptide induces cardiac hypertrophy but protects against heart failure during pressure overload.

DOI 10.1016/j.yjmcc.2021.01.004

mouseproteomics

𝕏 PostBluesky