Author

P. Most

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:biophysical modeling· 1 Organism:mouse· 1 Organism:plant (other)· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

J. Ritterhoff· 3 shared A. Jungmann· 2 shared D. Kehr· 2 shared E. Gao· 2 shared H. A. Katus· 2 shared J. Birkenstock· 2 shared K. Varadi· 2 shared M. Busch· 2 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPharmacology & Toxicology

J. Ritterhoff

Mutual co-authors in cluster

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3 papers

Recent·Most cited

S100A1ct: a synthetic peptide derived from human S100A1 protein improves cardiac contractile performance and survival in pre-clinical heart failure models

D. Kehr, J. Ritterhoff, M. Glaser, L. Jarosch, R. Salazar, K. Spaich, K. Varadi, J. Birkenstock, M. Egger, E. Gao, W. J. Koch, H. A. Katus, N. Frey, A. Jungmann, C. Busch, , P. Most

This paper develops a synthetic peptide S100A1ct that improves cardiac function and survival in heart failure models by enhancing Ca2+ cycling and targeting SERCA2a and RyR2.

bioRxiv · Mar 4, 2023Pharmacology & Toxicology

Cardiac-targeted rAAV5-S100A1 gene therapy protects against adverse remodeling and contractile dysfunction in post-ischemic hearts

D. Kehr, J. Salatzki, B. Krautz, K. Varadi, J. Birkenstock, P. Schlegel, E. Gao, W. J. Koch, J. Riffel, F. Andre, K. Peppel, H. A. Katus, N. Frey, M. Busch, H. Pfannkuche, , P. Most

This study demonstrates that cardiac-targeted rAAV5-S100A1 gene therapy reduces adverse remodeling and improves contractile function in post-ischemic hearts in pigs and mice.

bioRxiv · Mar 3, 2023 · PreprintPathology

SUMO interacting motif (SIM) of S100A1 is critical for S100A1 post-translational protein stability

Z. H. Jebessa, M. Glaser, J. Zhao, A. Schneider, R. Seenivasan, M. Busch, J. Ritterhoff, R. C. Wade, P. Most

This study identifies a SUMO interacting motif in S100A1 that regulates its post-translational stability through SUMO-mediated interactions.

bioRxiv · Jan 18, 2023 · PreprintBiochemistry