E. Gao

Podoplanin Positive Cell-derived Extracellular Vesicles Contribute to Cardiac Amyloidosis After Myocardial Infarction

This study identifies that Podoplanin-expressing mesenchymal stromal cells release exosomes that trigger SAA3 overproduction in macrophages, leading to cardiac amyloidosis after myocardial infarction.

Machine Learning Models for Cardiovascular Disease Prediction: A Comparative Study

This study compares KNN, logistic regression, and random forest for predicting cardiovascular disease using a Kaggle dataset, finding random forest to be the most accurate.

Loss of Myeloid Cell-Specific β2-Adrenergic Receptor Expression Ameliorates Cardiac Function and Remodeling after Acute Ischemia

This study shows that deleting β2AR in myeloid cells improves cardiac function and reduces fibrosis after heart attack by enhancing efferocytosis of neutrophils.

S100A1ct: a synthetic peptide derived from human S100A1 protein improves cardiac contractile performance and survival in pre-clinical heart failure models

This paper develops a synthetic peptide S100A1ct that improves cardiac function and survival in heart failure models by enhancing Ca2+ cycling and targeting SERCA2a and RyR2.

Cardiac-targeted rAAV5-S100A1 gene therapy protects against adverse remodeling and contractile dysfunction in post-ischemic hearts

This study demonstrates that cardiac-targeted rAAV5-S100A1 gene therapy reduces adverse remodeling and improves contractile function in post-ischemic hearts in pigs and mice.

Effect and mechanism of black soybean peptides alleviating oxidative damage in the celiac disease cell model

This study investigates how black soybean peptides alleviate oxidative damage caused by alpha gliadin peptide in a celiac disease cell model.

Enhanced Single RNA Imaging Reveals Dynamic Gene Expression in Live Animals

This paper introduces a method to image endogenous mRNAs in live animals with high temporal resolution and applies it to study gene expression dynamics in C. elegans epidermis.

Deep Phosphoproteomic Elucidation of Metformin-Signaling in Heterogenous Colorectal Cancer Cells

This study uses phosphoproteomics to analyze metformin signaling in CRC cell lines, revealing heterogeneous responses and identifying potential drug interactions.

Predicting the antigenic evolution of SARS-COV-2 with deep learning

This paper predicts SARS-CoV-2 antigenic evolution using MLAEP, a deep learning model that identifies mutations associated with immune escape and validates them through experiments.

Investigation on the changes of Bifidobacterium and lactic acid bacteria in soybean meal fermented feed

This study investigates how combining Bifidobacterium lactis with Bacillus coagulans or Lactobacillus paracasei enhances its growth during soybean meal fermentation under anaerobic conditions.

Lung Epithelial Cells Can Produce Antibodies Participating In Adaptive Humoral Immune Responses

The paper shows lung epithelial cells can produce TD-Ag-specific antibodies, dependent on CD4+ T cells, challenging the notion that B cells are the sole source of such antibodies.

A Peptide of the Amino-Terminus of GRK2 Induces Hypertrophy and Yet Elicits Cardioprotection after Pressure Overload

This study shows that a GRK2 amino-terminal peptide induces cardiac hypertrophy but protects against heart failure during pressure overload.

Activation or inhibition of PPARα-mediated fatty acid β-oxidation does not active cardiomyocyte proliferation in normal or infarcted adult mice

This study shows that activating or inhibiting PPAR-mediated fatty acid β-oxidation does not promote cardiomyocyte proliferation in adult mice, either under normal conditions or after myocardial infarction.