V. Poli

ANP32E drives vulnerability to ATR inhibitors by inducing R-loops-dependent Transcription Replication Conflicts in Triple Negative Breast Cancer

The paper identifies ANP32E as a driver of vulnerability to ATR inhibitors in triple-negative breast cancer by promoting R-loop-dependent transcription replication conflicts and genomic instability.

Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter.

The paper shows host-derived oxidized phospholipids initiate effector-triggered immunity, leading to lethality upon microbial encounter, and demonstrates that blocking oxPLs reduces inflammation and host death.

STAT3 restricts prostate cancer metastasis and antiandrogen resistance by controlling LKB1/CREB signaling pathway

This study identifies STAT3's role in restricting prostate cancer metastasis and antiandrogen resistance by regulating the LKB1/CREB signaling pathway in mouse models and human patients.

STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pigmentation pathway

This study shows that STAT3 promotes melanoma metastasis by repressing the MITF pigmentation pathway through CEBP induction.

The physical form of microbial ligands bypasses the need for dendritic cell migration to stimulate adaptive immunity

This study shows that soluble fungal polysaccharides are immunosilent in peripheral tissues but become potent immunogens in draining lymph nodes without requiring dendritic cell migration.

Network analysis allows to unravel breast cancer molecular features and to identify novel targets

This study uses network analysis on breast cancer gene expression data to identify molecular features and potential drug targets, particularly in basal-like breast cancer.

SP1 and STAT3 functionally synergize to induce the RhoU small GTPase and a subclass of non-canonical WNT responsive genes correlating with poor prognosis in breast cancer.

This study identifies SP1 and STAT3 cooperation in inducing RhoU and non-canonical WNT responsive genes linked to poor breast cancer prognosis.

MYC-driven epigenetic reprogramming favors the onset of tumorigensis by inducing a stem cell-like state

This study shows MYC induces an epigenetic reprogramming in mammary epithelial cells that promotes a stem cell-like state and tumor initiation in breast cancer.