Author

M. Lutolf

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Approach:experimental assay· 4 Organism:human· 4 Organism:mouse· 4 Research Focus:clustering· 3 Assay:scRNA-seq· 3 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2

Frequent Co-Authors

N. Broguiere· 2 shared S. Rezakhani· 2 shared A. Bucciarelli· 1 shared A. Chrisnandy· 1 shared A. E. Handel· 1 shared B. Deplancke· 1 shared B. Treutlein· 1 shared D. Klein· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersBioengineering

N. Broguiere

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

An integrated transcriptomic cell atlas of human endoderm-derived organoids

Q. Xu, L. Halle, S. Hediyeh-zadeh, M. Kuijs, U. Kilik, Q. Yu, T. Frum, L. Adam, S. Parikh, M. Gander, R. Kfuri-Rubens, D. Klein, Z. He, J. S. Fleck, K. Oost, , J. G. Camp

This paper creates a human endoderm organoid cell atlas by integrating single-cell transcriptomes from multiple organoid types to compare cell states with primary tissues and disease models.

bioRxiv · Nov 20, 2023Cell Biology

Developmental dynamics of the neural crest-mesenchymal axis in creating the thymic microenvironment

A. E. Handel, S. Cheuk, F. Dhalla, S. Maio, T. Hubscher, I. Rota, M. E. Deadman, O. Ekwall, M. Lutolf, K. Weinberg, G. Hollander

The paper uses single-cell profiling to analyze the dynamic changes in non-epithelial thymic stroma across development, identifying novel fibroblast subtypes and their roles in thymus organogenesis.

bioRxiv · Nov 8, 2021Immunology

3D confinement regulates stem cell fate

O. Y. Dudaryeva, A. Bucciarelli, G. Bovone, S. Jaydev, N. Broguiere, M. Al-Bayati, M. Lutolf, M. W. Tibbitt

This study shows that 3D geometric confinement influences human mesenchymal stem cell fate by modulating YAP localization and mechanotransduction pathways.

bioRxiv · May 2, 2021 · PreprintBioengineering

Deterministic scRNA-seq of individual intestinal organoids reveals new subtypes and coexisting distinct stem cell pools

J. Bues, M. Biocanin, J. Pezoldt, R. Dainese, A. Chrisnandy, S. Rezakhani, W. Saelens, V. Gardeux, R. Gupta, J. Russeil, Y. Saeys, E. Amstad, M. Claassen, M. Lutolf, B. Deplancke

The paper introduces DisCo, a deterministic scRNA-seq method for small tissue samples, revealing new intestinal organoid subtypes and stem cell populations.

bioRxiv · May 19, 2020 · PreprintBioengineering

Morphogenesis guided by 3D patterning of growth factors in biological matrices

N. Broguiere, I. Luechtefeld, L. Trachsel, D. Mazunin, J. Bode, M. Lutolf, M. Zenobi-Wong

The paper introduces a 2PP system for precise 3D patterning of growth factors in biological matrices, enabling axon guidance studies in brain-mimetic ECMs.

bioRxiv · Nov 7, 2019Bioengineering

Mechano-modulatory synthetic niches for liver organoid derivation

G. Sorrentino, S. Rezakhani, E. Yildiz, S. Nuciforo, M. Heim, M. Lutolf, K. Schoonjans

This study develops chemically defined hydrogels to derive mouse and human liver organoids, showing stiffness sensitivity and YAP/SFK dependence, and establishes biopsy-derived human liver organoids without animal components.

bioRxiv · Oct 18, 2019Bioengineering