T. Joshi

Anti-EGFR aptamer exhibits direct anti-cancer effects in NSCLC cells harboring EGFR L858R mutations

This study shows that an anti-EGFR aptamer reduces viability of NSCLC cells with EGFR L858R mutations and tumor burden in a mouse model, with cell line-dependent mechanisms.

Integrative phenotypic-transcriptomic analysis of soybean plants subjected to multifactorial stress combination

This study investigates the effects of multifactorial stress combinations on soybean plants, revealing negative cumulative impacts and unique transcriptomic responses in different tissues.

Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis

Integrative identification of non-coding regulatory regions driving metastatic prostate cancer

This study identifies non-coding regulatory regions driving metastatic prostate cancer using an integrative computational and experimental approach.

Adventitial macrophage accumulation impairs perivascular nerve function in mesenteric arteries with inflammatory bowel disease

This study shows that adventitial macrophage accumulation in mesenteric arteries with IBD impairs perivascular nerve function, particularly sensory vasodilation, which is reversed by macrophage depletion.

Inhibition of muscarinic receptor signaling protects human enteric inhibitory neurons against platin chemotherapy toxicity

This study identifies muscarinic receptor signaling as a key driver of platin-induced enteric neuropathy and shows that its inhibition protects neurons from toxicity.

The transcriptome of soybean reproductive tissues subjected to water deficit, heat stress, and a combination of water deficit and heat stress.

This study presents a transcriptomic dataset of soybean reproductive tissues under water deficit, heat stress, and their combination, revealing unique stress responses across tissues.

The effects of multifactorial stress combination on rice and maize

This study shows that multifactorial stress combinations negatively affect rice and maize growth, with proteomics revealing common stress-responsive proteins.

Differential transpiration between pods and leaves during stress combination in soybean

The paper shows that soybean pods and leaves exhibit differential transpiration under combined water deficit and heat stress, reducing internal pod temperature and protecting seed development.

Differential regulation of flower transpiration during abiotic stress in plants

The paper shows that under drought and heat stress, soybean plants open flower stomata to lower flower temperature, protecting reproduction at the expense of vegetative tissues.

An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus

The paper identifies HNRNPC and PABPC4 as regulators of alternative polyadenylation that suppress breast cancer metastasis by controlling mRNA translation.

Allosteric control of Ubp6 and the proteasome via a bidirectional switch

This study identifies an allosteric switch that controls Ubp6 and the proteasome, showing their active states are mutually exclusive.

Traceback of Core Transcription Factors for Soybean Root Growth Maintenance under Water Deficit

The paper identifies core transcription factors regulating root growth in soybean under water deficit by integrating phylogenetic analysis and transcriptome data.