Author

A. Arab

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:microscopy & imaging analysis· 2 Approach:statistical model· 2

Frequent Co-Authors

H. Goodarzi· 4 shared K. Garcia· 3 shared J. Xiao· 2 shared M. Lakadamyali· 2 shared A. Cesiulis· 1 shared A. K. Chemel· 1 shared A. Keshavarzi Arshadi· 1 shared A. Majd· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersCancer Biology

H. Goodarzi

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A multiomics approach reveals RNA dynamics promote cellular sensitivity to DNA hypomethylation

A. Y. Ge, A. Arab, R. Dai, A. Navickas, L. Fish, K. Garcia, H. Asgharian, J. Goudreau, S. Lee, K. Keenan, M. B. Pappalardi, M. T. McCabe, L. Przybyla, H. Goodarzi, L. Gilbert

This study identifies RNA dynamics as key regulators of cellular response to decitabine in AML cells using a multiomics and CRISPR approach.

Scientific Reports · Oct 29, 2024Peer-reviewedCancer Biology

Propagated circulating tumor cells uncovers the rople of NFκB and COP1 in metastasis

J. Xiao, U. Sharma, A. Arab, S. Miglani, S. Bhalla, S. Suguru, R. Suter, R. Mukherji, M. E. Lippman, P. R. Pohlmann, J. Zeck, J. L. Marshall, B. A. Weinberg, A. R. He, M. S. Noel, , S. Agarwal

This study develops a CTC and CDX platform to expand patient-derived CTCs and identifies NFκB and COP1 as drivers of metastasis.

Cancers · Mar 17, 2023Peer-reviewedCancer Biology

Inhibition of muscarinic receptor signaling protects human enteric inhibitory neurons against platin chemotherapy toxicity

M. N. Richter, S. Farahvashi, R. M. Samuel, H. Majd, A. K. Chemel, J. T. Ramirez, A. Majd, M. D. Scantlen, N. Elder, A. Cesiulis, K. Garcia, T. Joshi, M. G. Keefe, B. Samiakalantari, E. M. Turkalj, , F. Fattahi

This study identifies muscarinic receptor signaling as a key driver of platin-induced enteric neuropathy and shows that its inhibition protects neurons from toxicity.

bioRxiv · Mar 8, 2023 · PreprintPharmacology & Toxicology

Functional microRNA-Targeting Drug Discovery by Graph-Based Deep Learning

A. Keshavarzi Arshadi, M. Salem, H. Karner, K. Garcia, A. Arab, J. S. Yuan, H. Goodarzi

This study develops RiboStrike, a deep learning framework to identify small molecules targeting microRNAs, demonstrating its effectiveness in finding anti-miR-21 compounds with cancer therapeutic potential.

bioRxiv · Jan 13, 2023Cancer Biology

Detyrosination enrichment on microtubule subsets is established by the interplay between a stochastically-acting enzyme and microtubule stability

Q. Tang, S. Sensale, C. Bond, A. Qiao, S. Hugelier, A. Arab, G. Arya, M. Lakadamyali

The paper investigates how detyrosination of microtubules occurs on specific subsets through stochastic enzyme activity and microtubule stability interactions.

bioRxiv · Sep 29, 2022 · PreprintCell Biology

Tau forms oligomeric complexes on microtubules that are distinct from pathological oligomers in disease

M. T. Gyparaki, A. Arab, E. M. Sorokina, A. N. Santiago-Ruiz, C. H. Bohrer, J. Xiao, M. Lakadamyali

The paper uses SMLM to show physiological tau oligomers on microtubules differ from pathological oligomers and links phosphorylation states to aggregate species.

bioRxiv · Jul 7, 2020 · PreprintCell Biology