J. McCormack

Combining Scalable Organ Chip Platform with Deep Learning-Based Imaging Analysis for Cancer Therapeutic Screening

The paper combines an organ chip platform with deep learning for drug response analysis in cancer models, showing improved accuracy over traditional methods.

SARS-CoV-2 infects neurons, astrocytes, choroid plexus epithelial cells and pericytes of the human central nervous system

This study shows SARS-CoV-2 can infect neurons, astrocytes, choroid plexus epithelial cells, and pericytes in the human central nervous system, supporting a model of direct viral infection as a cause of neurological symptoms in COVID-19.

Darwin's Overlooked Radiation: genomic evidence points to the early stages of a radiation in the Galapagos prickly pear cactus (Opuntia, Cactaceae)

The paper presents genomic evidence of early radiation stages in Galapagos prickly pear cacti, highlighting geographic structure and candidate loci associated with adaptation.

First Eurasian cases of SARS-CoV-2 seropositivity in a free-ranging urban population of wild fallow deer

The paper reports the first cases of SARS-CoV-2 seropositivity in Eurasian fallow deer, showing increased seroprevalence with emerging variants.

Structure modeling hints at a granular organization of the Vertebrate Golgi ribbon

The paper models Golgi ribbon structures to understand their impact on Weibel-Palade body size, finding that a model with differentially functioning monomer and dimer ministacks best fits experimental data.

Single-particle cryo-EM at atomic resolution

This paper demonstrates achieving atomic resolution cryo-EM structures for membrane proteins and apo-ferritin using advanced hardware, enabling detailed structural analysis and hydrogen bonding visualization.

Genome-wide signals of drift and local adaptation during rapid lineage divergence in a songbird

The paper analyzes genome-wide SNP data from Oregon junco populations to assess the roles of drift and local adaptation in their divergence, finding evidence of both strong drift and local adaptation driven by environmental factors.

Phylogenomics of montane frogs of the Brazilian Atlantic Forest supports a scenario of isolation in sky islands followed by relative climatic stability

This study uses phylogenomic data to support a scenario of diversification-by-isolation in sky islands of the Brazilian Atlantic Forest due to climatic stability.